Ritonavir-d6(利托那韦 d6)
规格：500μg；价格：3800；
规格：1mg；价格:7000元。
产品描述
Ritonavir-d6 is intended for use as an internal standard for the quantification of ritonavir by GC- or LC-MS.
Ritonavir is an HIV protease inhibitor. It inhibits recombinant HIV-1 protease by 79% when used at a
concentration of 0.5 nM. It inhibits HIV-13B-induced cell death in MT-4 human T cell leukemia cells
(EC50 = 25 nM) as well as cell death induced by HIV-1LAI, HIV-2ROD, and HIV-2EHO in human MT-2
cells (IC50s = 0.045, 0.13, and 0.24 μM, respectively). Ritonavir also inhibits the cytochrome P450 (CYP)
isoform CYP3A (IC50 = 0.14 μM). It inhibits CYP-mediated oxidative metabolism of the HIV protease
inhibitors saquinavir , indinavir , nelfinavir , and amprenavir in rat and human liver microsomes in a
concentration-dependent manner. Ritonavir (10 mg/kg) also prevents decreases in plasma levels of
these four compounds in rats. Formulations containing ritonavir have been used in the treatment of HIV-1
infection.
化学数据
Catalog No.：MR720201
Cas No.：1217720-20-1
分子式：C37H42D6N6O5S2
分子量：727
Purity: >99.00%
溶解度：Chloroform: Slightly Soluble,DMSO: Slightly Soluble,Methanol: Slightly Soluble
储存条件：Store at -20°C
General tips：For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the
ultrasonic bath for a while.
Shipping Condition：Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
Chemical Structure：
