Darinaparsin

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产品名称: Darinaparsin

产品型号: MD819869

产品展商: 晶欣生物

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Darinaparsin

Cat.Not：MD819869

prices：5MG 1800

10MG 2800

Speciication

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 &#181M. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.[1]

Chemical Properties

Cas No.	69819-86-9	SDF
别名	Dimethylarsinic glutathione
化学名	L-γ-glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine
Canonical SMILES	OC(CNC([C@H](CS[As](C)C)NC(CC[C@H](N)C(O)=O)=O)=O)=O
分子式	C₁₂H₂₂AsN₃O₆S	分子量	411.3
溶解度	0.1mg/mL in ethanol and DMF, 10mg/mL in DMSO	储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

Chemical Structure