Infliximab

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产品名称: Infliximab

产品型号: PHM220230

产品展商: 晶欣生物

产品文档:

Infliximab Clinical Trial

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产品参数

品名	货号	CAS 号	纯度	规格	价格
Infliximab (Avakine)	PHM220230	170277-31-3	90.30%	1 mg	￥1200
				5 mg	￥3000
				25 mg	￥7500

产品简介

Infliximab (Avakine) 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。

Infliximab 可阻止 TNF-α 与 TNF-α 受体 1 (TNFR1) 和 TNFR2 的相互作用。

Infliximab 可用于自身 mianyi ，慢性炎症性 jibing 和糖尿病神经病变的研究。

详细介绍

生物活性	Infliximab (Avakine) is a chimeric monoclonal IgG1 antibody thatspecifically binds to TNF-α.Infliximab prevents the interaction of TNF-α with TNF-α receptor (TNFR1 and TNFR2).Infliximab has the potential for autoimmune, chronic inflammatory diseases and diabetic neuropathy research.
IC50 & Target	TNF-α
体外研究 (In Vitro)	TNF-α-treated adipocytes shows a significant 64% decrease in insulin-stimulated glucose uptake, whereas Infliximab (10 ng/mL) reverses TNF-α actions by significantly improving glucose incorporation in 3T3L1 adipocytes. Infliximab restores phosphorylation of substrate-2 and AKT by attenuating protein-tyrosine phosphatase 1B (PTP1B) activation. Infliximab ameliorates TNF-α-induced insulin resistance in 3T3L1 adipocytes in vitro by restoring the insulin signalling pathway via PTP1B inhibition. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (*In Vivo*)	A single injection of Infliximab (10 μg/g in 100 μl saline/dose ip) in diabetic TNF-α+/+) mice leads to suppression of the increased serum TNF-α and amelioration of the electrophysiological and biochemical deficits for at least 4 weeks. The increased TNF-α mRNA expression in diabetic dorsal root ganglion is also attenuated by Infliximab. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS 号	170277-31-3
中文名称	英夫利昔单抗
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.