Doxorubicin hydrochloride盐酸阿霉素

Doxorubicin hydrochloride盐酸阿霉素

货号：MD5142-50mg   350.00

Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride) 是一种有细胞毒性的蒽环类抗生素，常用作肿瘤化疗剂。Doxorubicin hydrochloride 抑制拓扑异构酶 II (topoisomerase-II)，从而抑制 DNA 复制。Doxorubicin hydrochloride 下调 AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。Doxorubicin hydrochloride 诱导凋亡 (apoptosis) 和自噬 (autophagy)

别名: Hydroxydaunorubicin Hydrochloride

Doxorubicin hydrochloride blocks RNA polymerase and reverse transcriptase. It also inhibits nucleic acid synthesis and induces apoptosis.

· Inhibits nucleic Acid synthesis

· Induces apoptosis

· Substrate of MRP1

Naturally fluorescent anthracycline antibiotic, anticancer drug

Doxorubicin Hydrochloride is a chemotherapeutic, antitumor, immunosuppressive, and antibiotic agent.

Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. The fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles (Golgi and lysosome) in the sequestration of drugs and its implication in drug resistant phenotypes.

Reddish orange powder

Soluble in water (>10 mg/mL), in isotonic sodium chloride, methanol, aqueous alcohols, DMSO (> 10 mg/mL); practically insoluble in chloroform, ether, and other organic solvents.